The UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17
Ontology highlight
ABSTRACT: One of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large proportion of the population, due to complete gene deletion. We defined the impact of a UGT2B17 deficiency on the proteome of normal human liver tissues by data-independent acquisition mass spectrometry.
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Chantal Guillemette
PROVIDER: MSV000095873 | MassIVE |
SECONDARY ACCESSION(S): PXD055894
REPOSITORIES: MassIVE
ACCESS DATA
