Proteomics

Dataset Information

0

Lactylation of Tau in Human Alzheimers Disease Brain


ABSTRACT: Aggregation of phosphorylated tau is associated with cognitive impairment in Alzheimers disease patients. In AD a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post-translational modification on proteins that conjugates lactyl groups to lysine residues known as lactylation. Our findings suggest that tau lactylation links metabolic dysregulation with tauopathies and could serve as a novel diagnostic and therapeutic target.

INSTRUMENT(S): Orbitrap Astral

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ning Wang  

PROVIDER: MSV000095881 | MassIVE |

SECONDARY ACCESSION(S): PXD055922

REPOSITORIES: MassIVE

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-04-17 | MSV000085305 | MassIVE
2019-03-30 | GSE121264 | GEO
2025-04-15 | GSE282910 | GEO
| FBgn0266579 | ExpressionAtlas
| FBgn0266579 | ExpressionAtlas
2018-11-26 | GSE111737 | GEO
2022-06-04 | PXD032389 | Pride
2022-06-04 | PXD032372 | Pride
2024-11-16 | GSE272794 | GEO
2025-01-24 | E-GEOD-18309 | ExpressionAtlas