Lactylation of Tau in Human Alzheimers Disease Brain

ABSTRACT: Aggregation of phosphorylated tau is associated with cognitive impairment in Alzheimers disease patients. In AD a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post-translational modification on proteins that conjugates lactyl groups to lysine residues known as lactylation. Our findings suggest that tau lactylation links metabolic dysregulation with tauopathies and could serve as a novel diagnostic and therapeutic target.

INSTRUMENT(S): Orbitrap Astral

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ning Wang  

PROVIDER: MSV000095881 | MassIVE |

SECONDARY ACCESSION(S): PXD055922

REPOSITORIES: MassIVE