Mitochondrial DNA affects tau expression and phosphorylation in Alzheimers Disease and aging in humans and cybrid cell lines

ABSTRACT: We investigate the role of mitochondrial DNA in Alzheimers Disease pathology using human cybrid cell lines and investigate the relationships between biomarker expression from cybrids and clinically relevant outcomes from the same individuals. Proteomic analysis of cybrids showed significant alterations in pathways related to mitochondrial dysfunction and energy synthesis in AD and mildly cognitively impared cybrids compared to cognitively healthy controls.

INSTRUMENT(S): Orbitrap Ascend

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jill K Morris  

PROVIDER: MSV000096065 | MassIVE | Fri Oct 11 07:49:00 BST 2024

SECONDARY ACCESSION(S): PXD056731

REPOSITORIES: MassIVE