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SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent cell types

ABSTRACT: There is an urgent need to comprehensively catalog senescence markers across the wide range of cell types in an organism. Here, we profiled the transcriptomes and proteomes of over 30 models of senescence in 14 different primary human cell types. We found that senescent cells from all tissue types do not share a unique marker, but they do share broadly activated or repressed pathways, namely pathways of damage response to elicit tissue repair, and unique metabolic pathways. Importantly, the combined use of some of the most widely shared senescence markers validated the presence of senescent-like cells in mice through single-cell RNA-sequencing and immunostaining approaches. The enclosed catalog represents a much-needed resource to identify senescent cells across tissues in the body.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Nathan Basisty

PROVIDER: MSV000096215 | MassIVE | Fri Oct 25 06:46:00 BST 2024

REPOSITORIES: MassIVE

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