Dataset Information

Serum N-glycomics with nanoLC-QToF LC-MS/MS reveals N-glycan biomarkers for glioblastoma, meningioma, and high-grade meningioma

ABSTRACT: Alteration of glycosylation in cancer cells leaded to the expression of tumor-associated glycans that could be used as a biomarker for diagnosis and prognostic prediction of the diseases. In this study, we used nanoLC-QToF LC-MS/MS for the identification of serum N-glycan biomarkers for detection of brain tumors. We identified the increase of sialylated N-glycans and decrease of fucosylated N-glycans in serum of patients with glioblastoma (GBM) and meningioma (MG) compared with healthy persons.

INSTRUMENT(S): 6520A Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Carlito B. Lebrilla