Gut-microbiota derived N,N,N-trimethyl-5-aminovaleric acid (TMAVA) is a modulator of CNS-aGVHD

ABSTRACT: In this study, we report that microbiota depletion results in exacerbated acute graft-vs-host disease in the central nervous system (CNS), mediated by microglia activation and T-cell infiltration. We could rescue the inflammatory changes in the CNS by administering the microbiota-derived metabolite N,N,N-trimethyl-5-aminovalerate.

INSTRUMENT(S): 6495B Triple Quadrupole LC/MS

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Prof. Dr. Robert Zeiser  

PROVIDER: MSV000096417 | MassIVE | Thu Nov 14 06:30:00 GMT 2024

REPOSITORIES: MassIVE