Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Amber Mosley
PROVIDER: MSV000096625 | MassIVE | Mon Dec 09 12:43:00 GMT 2024
SECONDARY ACCESSION(S): PXD058705
REPOSITORIES: MassIVE
Sheth Aditya S AS Chan Ka-Kui KK Liu Sheng S Wan Jun J Angus Steve P SP Rhodes Steven D SD Mitchell Dana K DK Davis Christopher C Ridinger Maya M Croucher Peter J PJ Zeidan Amer M AM Wijeratne Aruna A Qian Shaomin S Tran Ngoc Tung NT Sierra Potchanant Elizabeth A EA
Cancer research communications 20250401 4
<h4>Abstract</h4>Overall survival of acute myeloid leukemia (AML) remains limited. Inhibitors of the master mitotic kinase PLK1 have emerged as promising therapeutics, demonstrating efficacy in an undefined subset of patients with AML. However, the clinical success of PLK1 inhibitors remains hindered by a lack of predictive biomarkers. The Fanconi anemia (FA) pathway, a tumor-suppressive network comprised of at least 22 genes, is frequently mutated in sporadic AML. In this study, we demonstrate ...[more]