Iron-restricted Mycobacterium tuberculosis exports pathogenicity factors packed in extracellular vesicles
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ABSTRACT: Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, responds to iron limitation by upregulating extracellular vesicle (EV) production. This study examined the protein composition of induced Mtb vesicles using chromatography coupled with mass spectrometry. The findings revealed vesicle packaging of critical pathogenicity effectors, including proteins that promote bacterial survival, immune evasion, and inflammation. The results are relevant to the fundamental understanding of Mtb-host interactions and can guide efforts to develop vesicle-based TB biomarkers.
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Mycobacterium Tuberculosis
SUBMITTER:
Rodriguez, Gloria
PROVIDER: MSV000096784 | MassIVE | Mon Jan 06 12:27:00 GMT 2025
REPOSITORIES: MassIVE
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