Proteomics

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Iron-restricted Mycobacterium tuberculosis exports pathogenicity factors packed in extracellular vesicles


ABSTRACT: Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, responds to iron limitation by upregulating extracellular vesicle (EV) production. This study examined the protein composition of induced Mtb vesicles using chromatography coupled with mass spectrometry. The findings revealed vesicle packaging of critical pathogenicity effectors, including proteins that promote bacterial survival, immune evasion, and inflammation. The results are relevant to the fundamental understanding of Mtb-host interactions and can guide efforts to develop vesicle-based TB biomarkers.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Mycobacterium Tuberculosis

SUBMITTER: Rodriguez, Gloria  

PROVIDER: MSV000096784 | MassIVE | Mon Jan 06 12:27:00 GMT 2025

REPOSITORIES: MassIVE

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