Dataset Information

Mouse brain proteome response to a circadian rhythm disruption and FABP7 KO

ABSTRACT: Proteomic data from mouse brain; frontal cortical/hippocampal, encompassing Sham control and Fabp7 KO combined with circadian rhythm disrupting electroshock. 16 total samples. Samples were digested with trypsin, TMT labeled and fractionated (12) then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS processing pipeline.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jon M. Jacobs

PROVIDER: MSV000097187 | MassIVE | Fri Feb 21 10:28:00 GMT 2025

SECONDARY ACCESSION(S): PXD061063

REPOSITORIES: MassIVE

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Publications

Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain.

Berg Adam P AP Tariq Shahroz H SH Flores Carlos C CC Lefton Micah M Owada Yuji Y Davis Christopher J CJ Ferraro Thomas N TN Jacobs Jon M JM Gritsenko Marina A MA Lee Yool Y Schroeder Wheaton L WL Gerstner Jason R JR

Neuroglia (Basel, Switzerland) 20250903 3

<h4>Background/objectives</h4>Patients with epilepsy commonly experience patterns of seizures that change with sleep/wake behavior or diurnal rhythms. The cellular and molecular mechanisms that underlie these patterns in seizure activity are not well understood but may involve non-neuronal cells, such as astrocytes. Our previous studies show the critical importance of one specific astrocyte factor, the brain-type fatty acid binding protein Fabp7, in the regulation of time-of-day-dependent electr ...[more]

PMID: 41346369

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