Proteomics

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Proteomic analysis of bone marrow CD138+ cells to identify proteins associated with the response of multiple myeloma patients to commonly used therapeutic regimens.

ABSTRACT: Multiple Myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs resistance mechanisms are involved in the failure of therapies to eradicate the disease. This study aims to identify proteins significantly impacting MM patients' response to commonly used therapeutic regimens. Bone marrow CD138+ selected plasma cells were isolated from patients that had achieved Response (Responders, R) and those who were Non-Responders (NR) to their primary MM therapy. We used LC-MS/MS to investigate the proteomic profile of MM samples, followed by statistical and bioinformatics analysis. Collectively, proteomics data obtained from R and NR to MM therapy displayed significant changes in the immune system and protein synthesis regulation, supporting their potential role in progression and therapeutic response of MM.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jerome Zoidakis  

PROVIDER: MSV000097497 | MassIVE | Wed Apr 02 09:17:00 BST 2025

SECONDARY ACCESSION(S): PXD062530

REPOSITORIES: MassIVE

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Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs' resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients' response to commonly used therapeutic regimens. Bone marrow CD138+ selected plasma cells were isolated from patients who had achieved Response (Responders, R) and those who were Non-Responders (NR) to their primary MM therapy. We used LC-MS/MS to investig  ...[more]

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