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Characterization of the cyclic dipeptide cyclo(His-Pro) in Arabidopsis

ABSTRACT: The iTSA experiment was designed to map putative protein targets of cyclic dipeptides in Arabidopsis.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702)

SUBMITTER: Aleksandra Skirycz

PROVIDER: MSV000097655 | MassIVE | Thu Apr 17 11:26:00 BST 2025

REPOSITORIES: MassIVE

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Characterization of the cyclic dipeptide cyclo(His-Pro) in Arabidopsis.

Minen Romina I RI Camalle Maria Dolores MD Schwertfeger Tyler J TJ Abdulhakim Fatimah F Reish Hannah H Perez de Souza Leonardo L Moreno Juan C JC Schilmiller Anthony A Thirumalaikumar Venkatesh P VP Agarwal Pallavi P Plecki Caroline F CF Fernie Alisdair R AR Hirt Heribert H Schroeder Frank C FC Skirycz Aleksandra A

Plant physiology 20250401 1

Diketopiperazines (DKPs) are chemically and functionally diverse cyclic dipeptides associated primarily with microbes. Few DKPs have been reported from plants and animals; the best characterized is cyclo(His-Pro), found in the mammalian central nervous system, where it arises from the proteolytic cleavage of a thyrotropin-releasing tripeptide hormone. Herein, we report the identification of cyclo(His-Pro) in Arabidopsis (Arabidopsis thaliana), where its levels increase upon abiotic stress condit ...[more]

PMID: 40317191

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