Characterization of cytokine treatment on human pancreatic islets by top-down proteomics

ABSTRACT: Top-down proteomic data from 6 human islet donors; islets were treated with interferon gamma (IFN-gamma) and interleukin-1 beta (IL-1 beta). Time points include t=0 (control) and t=24 hours for each donor. Samples were reduced and alkylated, then analyzed by LC-MS/MS. Data was searched with TopPIC using PNNL's DMS processing pipeline and post-processed with TopPICR.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Wei-Jun Qian  

PROVIDER: MSV000097810 | MassIVE | Tue May 06 11:29:00 BST 2025

REPOSITORIES: MassIVE