Proteomics

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Androgenic Effects of 11-oxyandrogens in Castration-Resistant Prostate Cancer


ABSTRACT: Investigations of CRPC cell models demonstrate that 11-ketotestesterone (11KT) and 11-hydroxytestosterone (11OHT) drive robust AR-mediated proliferative responses and significantly modulate gene and protein expression profiles, paralleling canonical androgens. They also exhibit unique transcriptional and post-transcriptional effects that include potential AR-independent pathways. Furthermore, the AR antagonist enzalutamide effectively inhibits their androgenic actions, suggesting they are primarily AR-mediated.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Chantal Guillemette  

PROVIDER: MSV000097860 | MassIVE | Tue May 13 13:28:00 BST 2025

SECONDARY ACCESSION(S): PXD063893

REPOSITORIES: MassIVE

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