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Impact of clozapine and risperidone on the proteome of the rat prefrontal cortex (PFC) and remaining cortex (CX)

ABSTRACT: This study investigates the molecular mechanisms of action of clozapine and risperidone in the rat brain, specifically targeting the prefrontal cortex (PFC) and the remaining cortical regions (CX). A multi-platform proteomic approach was employed to capture comprehensive changes in protein expression induced by chronic (21 days) antipsychotic drug treatment.

INSTRUMENT(S): Orbitrap Astral, Q Exactive

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Sylwia Kedracka-Krok

PROVIDER: MSV000097948 | MassIVE | Wed May 21 05:26:00 BST 2025

SECONDARY ACCESSION(S): PXD064145

REPOSITORIES: MassIVE

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