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Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM

ABSTRACT: All these samples are fibrils isolated from patient tissues of different organs. Intact Mass Analysis: ID 1175196 - ApoAI-R173P - Heart ID 1175197 - ApoAI-R173P - Kidney ID 1175198 - ApoAI-R173P - Liver ID 1175199 - ApoAI-R173P - Spleen ID 1175200 - ApoAI-G26R - Kidney ID 1175201 - ApoAI-G26R - Liver ID 1175202 - ApoAI-G26R - Spleen ID 1175203 - ApoAI-L90P - Heart Trypsin digestion, LC-MS/MS: ID 1151139 - ApoAI-R173P - Heart, Contain both Wild type and mutant Arg173Pro ID 1175177 - ApoAI-R173P - Kidney, Contain both Wild type and mutant Arg173Pro ID 1175178 - ApoAI-R173P - Liver, Contain both Wild type and mutant Arg173Pro ID 1175179 - ApoAI-R173P - Spleen, Contain both Wild type and mutant Arg173Pro ID 1175180 - ApoAI-G26R - Kidney, Contain both Wild type and mutant Gly26Arg ID 1175181 - ApoAI-G26R - Liver, Contain both Wild type and mutant Gly26Arg ID 1175182 - ApoAI-G26R - Spleen, Contain both Wild type and mutant Gly26Arg ID 1175183 - ApoAI-L90P - Heart, Contain both Wild type and mutant Leu90Pro GluC digestion, LC-MS/MS ID 1160261 - ApoAI-R173P - Heart, Contain both Wild type and mutant Arg173Pro

INSTRUMENT(S): Sciex X500B QTOF, Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Lorena Saelices Gomez

PROVIDER: MSV000098187 | MassIVE | Fri Jun 13 07:24:00 BST 2025

REPOSITORIES: MassIVE

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