Plasma Proteomics from Subjects with Abdominal Aortic Aneurysm
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Merry L. Lindsey
PROVIDER: MSV000099209 | MassIVE |
REPOSITORIES: MassIVE
Similar Datasets
Project description:Maternal plasma samples collected longitudinally from pregnant women were profiled using SomaLogic aptamer-based assays in women with normal pregnancy and those who delivered preterm. DiagnosisGA is the gestational age at diagnosis with any disease indicated by the Group variable, and it is set to NA for normal pregnancies. In the Group variable, sPTD stands for spontaneous preterm delivery, and PPROM for preterm premature rupture of membranes. Additional longitudinal samples of the controls, including the two samples included herein, are also available and described in PMID: 28738067.
2021-05-24 | GSE150167 | GEO
Project description:Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer’s disease pathogenesis in the brain. While age-associated blood-borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. Here we investigate whether APOE allelic variation or presence of brain amyloid are associated with plasma proteomic changes and the molecular processes associated with these changes. Using the SOMAscan assay, we measured 1,305 plasma proteins from 53 homozygous, APOE3 and APOE4 subjects without dementia. We investigated the relationship of either the APOE-ε4 allele or amyloid positivity with plasma proteome changes by linear mixed effects modeling and ontology-based pathway and module trait correlation analyses. APOE4 is associated with plasma protein differences linked to atherosclerosis, tyrosine kinase activity, cholesterol transport, extracellular matrix, and synaptogenesis pathways. Independent of APOE4, we found that subjects likely harboring brain amyloid exhibit plasma proteome signatures associated with AD-linked pathways, including neurovascular dysfunction. Our results indicate that APOE4 status or presence of brain amyloid are associated with plasma proteomic shifts prior to the onset of symptoms, suggesting that systemic pathways in certain risk contexts may be plausible targets for disease modification.
2025-02-19 | GSE275392 | GEO
Project description:There are a lot of non-coding RNAs in human plasma. Some of them could be a biomarker of diseases. We used microarrys to detect lncRNAs in plasma of 10 control subjects and 10 heart failure (HF) patients diagnosed with dilated cardiomyopathy (DCM) and we identified distinct classes of dysregulated lncRNAs.
2019-01-15 | GSE124401 | GEO
Project description:Fatal COVID-19 is often complicated by hypoxemic respiratory failure and acute respiratory distress syndrome (ARDS). Mechanisms governing lung injury and repair in ARDS remain poorly understood because there are no biomarker-targeted therapeutics for patients with ARDS. We hypothesized that plasma proteomics may uncover unique biomarkers that correlate with disease severity in COVID-19 ARDS. We analyzed the circulating plasma proteome from 32 patients with ARDS and COVID-19 using an aptamer-based platform, which measures 7289 proteins, and correlated protein measurements with sequential organ failure assessment (SOFA) scores at 2 time points (Days 1 and 7 following ICU admission). We compared differential protein abundance and SOFA scores at each individual time point and identified 119 proteins at Day 1 and 46 proteins at Day 7 that correlated with patient SOFA scores. We modeled the relationship between dynamic protein abundance and changes in SOFA score between Days 1 and 7 and identified 39 proteins that significantly correlated with changes in SOFA score. Using Ingenuity Pathway Analysis, we identified increased ephrin signaling and acute phase response signaling correlated with increased SOFA scores over time, while pathways related to pulmonary fibrosis signaling and wound healing had an inverse relationship with SOFA scores between Days 1 and 7. These findings suggest that persistent inflammation may drive worsened disease severity, while repair processes correlate with improvements in organ dysfunction over time. This approach is generalizable to more diverse ARDS cohorts for identification of protein biomarkers and disease mechanisms as we strive towards targeted therapies in ARDS.
2025-04-09 | GSE283501 | GEO
Project description:Bicuspid aortic valve (BAV) is the most common congenital heart anomaly and is prone to cause complications, such as valvular stenosis and thoracic aortic dilation. There is currently no reliable way to predict the progression rate to thoracic aortic aneurysm. Here, we aimed to characterize the proteomic landscape in the plasma of stenotic BAV patients and provide potential biomarkers to predict progressive aortic dilation. Plasma samples were obtained from 45 subjects (30 stenotic BAV patients and 15 healthy controls). All samples were properly prepared and analyzed using mass spectrometry (MS)-based label-free quantitative proteomics.
2021-08-19 | PXD027125 | Pride
Project description:Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrinogen and citrullinated fibrinogen, and further epitope spreading resulting in additional targeting of fibronectin, collagen type V, cartilage gp39, and clusterin.
2009-09-12 | GSE18024 | GEO
Project description:Blood plasma from patients diagnosed with different subtypes of lung cancer or subjects with benign nodules was analyzed by using isobaric labeling and correlating to plasma thermograms. Plasma samples were digested using a FASP approach, labeled with TMT11plex reagents, admixed, deglycosylated using NEB Deglycoslylation Mix II in a non-denaturing approach. Deglycosylated peptides were eluted and analyzed by 1DLC-(low pH RP C-18)-MS. Collected data were analyzed by PD 2.1 using SequestHT and Mascot considering N-linked de-glycosylation of plasma proteins with Asn>Asp and Gln>Glu conversions along with standard modifications (TMT, Met(ox), Cys(CAM)) using an Orbitrap ELITE mass spectrometer. TMT reporter ion values were normalized to pooled internal standard TMT131 label and median glycopeptide abundance values of selected proteins were compared between control subjects and LC patients.
2021-08-18 | MSV000088001 | MassIVE
Project description:Extracellular RNA profiling of serum, plasma, and urine of healthy subjects
| PRJNA878918 | ENA
Project description:Plasma circRNA sequencing in normal subjects and patients with atrial fibrillation
| PRJNA551433 | ENA
Project description:Extracellular RNA profiling of serum, plasma, and urine of healthy subjects
| PRJNA878917 | ENA