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Effects of clozapine and risperidone on the proteome of human neurons derived from Lund Human Mesencephalic (LUHMES) cells

ABSTRACT: This study investigates the molecular mechanisms of action of clozapine and risperidone in human neurons derived from Lund Human Mesencephalic (LUHMES) cells. A DDA and DIA proteomic approach was employed to capture comprehensive changes in protein expression induced by chronic (72 hours) antipsychotic drug treatment. Additionally to the whole-cell lysate, the nuclear sub-proteome of LUHMES neurons was analysed using the DIA approach.

INSTRUMENT(S): Orbitrap Astral, Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Sylwia Kedracka-Krok

PROVIDER: MSV000099217 | MassIVE |

SECONDARY ACCESSION(S): PXD068480

REPOSITORIES: MassIVE

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