Dataset Information

Proteomics analysis of human aorta samples

ABSTRACT: Proteomics analysis of healthy human aourta and ruptured lesions were performed. The oxidation of hemoglobin was investigated.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Gergo Kallo

PROVIDER: MSV000099477 | MassIVE | Tue Oct 14 00:24:00 BST 2025

SECONDARY ACCESSION(S): PXD069425

REPOSITORIES: MassIVE

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Publications

Oxidation of hemoglobin to ferryl hemoglobin contributes to remodeling of the artery wall in abdominal aortic aneurysm.

Ding Yuchao Y Potor László L Katona Éva É Sótonyi Péter P Szappanos Ágnes Á Gyurok Gergő Péter GP Méhes Gábor G Hendrik Zoltán Z Fintha Attila A Gergely Péter Attila PA Benyó Zoltán Z Combi Zsolt Z Sikura Katalin Éva KÉ Beke Lívia L Nemeth Norbert N Balazs Szabo S Fürtös Ibolya I Kalló Gergő G Csősz Éva É Póliska Szilárd S Patsalos Andreas A Debus E Sebastian ES Nagy László L Balla György G Balla József J

Redox biology 20251028

Abdominal aortic aneurysm (AAA) with potentially fatal outcomes affects cardiovascular health via inflammation-related abnormalities. We revealed the presence of the oxidized hemoglobin (Hb), ferrylHb in the circulation in patients diagnosed with ruptured AAA. The aim of our study was to identify the source of oxidation of Hb in human hemorrhaged AAA and in an angiotensin II provoked AAA model in mice leading to generation of ferrylHb and to describe its fate in the pathophysiology. We demonstra ...[more]

PMID: 41197181

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