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Proteomics analysis of mouse aorta samples

ABSTRACT: Proteomics analysis of mouse abdominal aorta were performed. The oxidation of hemoglobin was investigated.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Gergo Kallo

PROVIDER: MSV000099478 | MassIVE | Tue Oct 14 00:29:00 BST 2025

SECONDARY ACCESSION(S): PXD069426

REPOSITORIES: MassIVE

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Oxidation of hemoglobin to ferryl hemoglobin contributes to remodeling of the artery wall in abdominal aortic aneurysm.

Ding Yuchao Y Potor László L Katona Éva É Sótonyi Péter P Szappanos Ágnes Á Gyurok Gergő Péter GP Méhes Gábor G Hendrik Zoltán Z Fintha Attila A Gergely Péter Attila PA Benyó Zoltán Z Combi Zsolt Z Sikura Katalin Éva KÉ Beke Lívia L Nemeth Norbert N Balazs Szabo S Fürtös Ibolya I Kalló Gergő G Csősz Éva É Póliska Szilárd S Patsalos Andreas A Debus E Sebastian ES Nagy László L Balla György G Balla József J

Redox biology 20251028

Abdominal aortic aneurysm (AAA) with potentially fatal outcomes affects cardiovascular health via inflammation-related abnormalities. We revealed the presence of the oxidized hemoglobin (Hb), ferrylHb in the circulation in patients diagnosed with ruptured AAA. The aim of our study was to identify the source of oxidation of Hb in human hemorrhaged AAA and in an angiotensin II provoked AAA model in mice leading to generation of ferrylHb and to describe its fate in the pathophysiology. We demonstra ...[more]

PMID: 41197181

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Proteomics analysis of human aorta samples

Project description:Proteomics analysis of healthy human aourta and ruptured lesions were performed. The oxidation of hemoglobin was investigated.

2025-10-14 | MSV000099477 | MassIVE

Single-cell RNA sequencing analysis of Angiotensin II-induced mouse dissecting AAA samples

Project description:Dissecting abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Complex, complicated, and extremely heterogeneous diseases like dissecting AAAs severely limit our ability to understand it. A thorough understanding of cell types and signaling pathways associated with the initiation and progression of dissecting AAA is essential for the development of medical therapy. Single-cell RNA sequencing (scRNA-seq) was performed on the abdominal aortas from ApoE-/- mice at days 28 post-Angiotensin II-induced mouse dissecting AAAs. According to the Angiotensin II-induced dissecting AAA model described in this study, alterations in cellular subpopulations, fractions, and transcriptome profiles are present.

2024-09-19 | GSE239620 | GEO

Expression profiling of mRNAs and long noncoding RNAs in mouse Abdominal Aortic Aneurysm (AAA)

Project description:mRNA and Long noncoding RNA profiles in the mouse abdominal aorta with AAA and without AAA.

2017-08-01 | GSE63396 | GEO

Real-time quantitative PCR analysis of rat aorta samples after stent deployment

Project description:Bare Metal Stents (BMS), Drug Eluting Stent (DES) and Exosomes Eluting Stent (EES) were placed in rat abdominal aorta for one week. Then total RNA of aortas was extracted. We used ScienCell's GeneQuery Rat Macrophage Polarization Markers qPCR Array Kit to quantitate gene expression of macrophage relevant genes.

2021-04-30 | GSE155793 | GEO

Difference analysis of microRNAs in abdominal aorta of ApoE-/- AngII-induced abdominal aortic aneurysm mices

Project description:Abdominal aortic aneurysm (AAA) is a vascular disease with high incidence at present.There is no effective drug treatment. MicroRNAs(miRNAs) play a regulatory role in the occurrence and development of AAA,and miRNA therapy is a promising treatment for AAA. The purpose of this study was to explore the differential expression of miRNAs in abdominal aorta of ApoE-/- AngII-induced abdominal aortic aneurysm mices. We used miRNA array to analyze miRNA differences in abdominal aorta between mices with ApoE-/- AngII-induced abdominal aortic aneurysm and ApoE-/-.

2025-10-29 | GSE280216 | GEO

Single-cell RNAseq analysis of CaCl2-induced mouse abdominal aortic aneurysm (AAA) samples

Project description:We performed single-cell RNA sequencing (scRNA-seq) on infrarenal abdominal aortas from C57BL/6J mice after perivascular CaCl2 treatment. Infrarenal abdominal aortas were collected four days after AAA induction and processed for sequencing. These data provide high-resolution insight into the complexity and heterogeneity of mouse AAA.

2021-03-15 | GSE164678 | GEO

Comparison of infrarenal and suprarenal sections of mouse ApoE-/- abdominal aorta

Project description:The ApoE -/- mice model of abdominal aortic aneurysm (AAA) involves introducing Angiotensin II subcutaneously to 14 week old male mice for 4 weeks by osmotic pump. A significant number of mice will develop aneurysm-like dilations in the suprarenal section of the abdominal aorta (SRA) that have a number of similarities to the human condition and make this a useful model of AAA. The mouse infrarenal aorta is very resistant to aneurysm formation while in humans AAA predominately occurs in the infrarenal section of the aorta (IRA). There have been a number of theories proposed to explain the site selctivity of aneurysm formation in AAA and this mice model. This study was designed to ascertain differences between SRA and IRA that may explain this site selectivity. Keywords: tissue type comparison

2010-05-12 | GSE7006 | GEO

Transcriptome analysis of the perivascular adipose tissue in peripheral artery disease patients

Project description:Perivascular adipose tissue (PVAT) is thought to play a role in vascular homeostasis and in the pathogenesis of diseases of large vessels. We tested the hypothesis that locally restricted transcriptional profiles characterize the PVAT localized at the site of the obstruction of the abdominal aorta in peripheral artery disease (PAD) patients. By a genome-wide approach and a paired-samples design, we investigated the PVAT transcriptome of 11 PAD patients with occlusive and with stenotic abdominal aortic lesions. We performed a data adjustment step using the DaMiRseq R/Bioconductor package, to remove the effect of confounders as produced by high-throughput gene expression techniques. We compared PVAT of the distal versus the proximal aorta of each patient to limit the effect of inter-individual variability, using the limma R/Bioconductor package. We did not find consistent differences in PVAT gene expression clearly distinguishing the two PVAT of the same patient. However, we found significant differences by comparing patients with total occlusive versus those with stenotic abdominal aortic lesions. We dissected putative mechanisms associated with PVAT involvement in PAD patients with total occlusive and with stenotic abdominal aorta lesions through a functional enrichment network analysis: cholesterol, sterol and alcohol biosynthetic process were enriched in patients with total occlusive lesions, whereas pathways recalling the structure maintenance and remodeling of the vessels were associated with patients with stenotic lesions. Our results would suggest that the PVAT transcriptome at the distal aorta site is associated with the degree of the atherosclerotic burden in PAD patients and that this effect can probably account for a diffuse (systemic) process affecting homogenously the PVATs spanning along the distal aorta rather than a singular specific trait.

2020-04-20 | GSE136822 | GEO

The mouse aging proteomic atlas

Project description:This database provides TMT-labeled proteomic data of aorta (thoracic aorta), brain, heart, kidney, liver, lung, muscle (gastrocnemius muscle), and skin (abdominal skin) of 6, 15, 24, and 30 months old male C57BL/6 mice. In addition to the whole-tissue lysate, low-soluble protein-enriched fraction was also analyzed for heart, kidney, lung, muscle, and skin. Bulk RNA-Seq data are available for brain, heart, kidney, liver, lung, muscle, and skin. The tissues used for transcriptomic analysis and proteomic analysis of whole-tissue lysate and low-soluble protein-enriched fraction were collected from the same mice. All analyses were conducted with 4 biological replicates.

2024-09-17 | PXD040722 | Pride

RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues

Project description:Abdominal aortic aneurysm (AAA) is a permanent segmental dilatation of the abdominal aorta, contributing to a high mortality once rupture. We performed RNA-sequencing analysis of abdominal aorta tissues from 14 participants, including seven patients with AAA and seven control individuals.

2023-12-07 | GSE183464 | GEO

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