Combinatorial Use of VHL and KEAP1 PROTACs Reveals Unexpected Synergy and Hook Effect Relief
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Astral
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Luca Busino
PROVIDER: MSV000099550 | MassIVE | Tue Oct 21 08:11:00 BST 2025
SECONDARY ACCESSION(S): PXD069729
REPOSITORIES: MassIVE
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Project description:The combinatorial use of two PROTACs recruiting the VHL and KEAP1 E3 ligases synergistically promotes target degradation and overcomes the hook effect.
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