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XIAMENUNIVERSITY-QIUYAN-8-Macrocarpal D (ykz0618)

ABSTRACT: Macrocarpal D is a bioactive constituent derived from Myrtaceae plants, exhibiting potent anti-inflammatory and free radical-scavenging activities, with promising application potential in pharmaceutical development, cosmetics, and natural product innovation.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Eucalyptus Globulus (ncbitaxon:34317)

SUBMITTER: QIUYAN

PROVIDER: MSV000099611 | MassIVE | Mon Oct 27 01:32:00 GMT 2025

REPOSITORIES: MassIVE

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XIAMENUNIVERSITY-QIUYAN-5-Macrocarpal C (ykz0704)

Project description:Macrocarpal C is a bioactive constituent extracted from Myrtaceae plants, exhibiting remarkable anti-inflammatory and antioxidant properties, with potential uses in pharmaceuticals, cosmetics, and natural product innovation.

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XIAMENUNIVERSITY-QIUYAN-3-Macrocarpal B (ykz0207)

Project description:Macrocarpal B is a bioactive metabolite from Myrtaceae plants, featuring notable anti-inflammatory and free radical-scavenging abilities, with potential applications in pharmaceuticals, cosmetics, and natural product development.

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XIAMENUNIVERSITY-QIUYAN-7-Macrocarpal H (ykz5101)

Project description:Macrocarpal H is a bioactive compound extracted from Myrtaceae plants, possessing remarkable anti-inflammatory and antioxidant capacities, with promising application prospects in pharmaceutical R&D, cosmetics, and natural product innovation.

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XIAMENUNIVERSITY-QIUYAN-2-Macrocarpal A (ykz0204)

Project description:Macrocarpal A, a key bioactive constituent isolated from Myrtaceae species like Eucalyptus, exhibits potent anti-inflammatory and antimicrobial effects, holding promise for pharmaceutical development and natural product applications.

2025-10-27 | MSV000099605 | MassIVE

XIAMENUNIVERSITY-QIUYAN-4-Macrocarpal G (ykz1006)

Project description:Macrocarpal G is a bioactive compound derived from Myrtaceae plants, possessing prominent anti-inflammatory and antioxidant activities, and it shows promising application prospects in pharmaceutical and cosmetic research.

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XIAMENUNIVERSITY-QIUYAN-1-Macrocarpal Q (ykz1410)

Project description:Macrocarpal Q is a bioactive compound from Myrtaceae plants, with anti-inflammatory and antioxidant properties. It shows potential in skincare and pharmaceutical research, valued for its natural origin and biological activity.

2025-10-27 | MSV000099604 | MassIVE

XIAMENUNIVERSITY-QIUYAN-14-Noreucalyptol (ykz1103)

Project description:Noreucalyptol, a nor-derivative of eucalyptol and natural terpenoid, is sourced from Eucalyptus plants. It possesses bioactivities such as anti-inflammatory properties, with potential applications in pharmaceuticals, cosmetics, and natural product innovation.

2025-10-27 | MSV000099618 | MassIVE

XIAMENUNIVERSITY-QIUYAN-11-Euglobal III (ykz0403)

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2025-10-27 | MSV000099615 | MassIVE

Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by GHKL ATPase gene therapy

Project description:Mutations in the Microrchidia CW-Type Zinc Finger 2 (MORC2) GHKL ATPase module cause Charcot Marie Tooth type 2Z or a broad range of neuropathy, but etiology and therapeutic strategy are not fully defined. Previously, we reported that the Morc2a p.S87L mouse model led to neuropathy and muscular dysfunction through DNA damage accumulation. This study revealed that Morc2a p.S87L caused a protein synthesis defect, resulting in the loss of function of Morc2a and weakening its function of maintaining DNA integrity and hydroxyl radical scavenging in the GHKL ATPase domain. Morc2a GHKL ATPase domain was considered a therapeutic target based on its function of simultaneously complementing hydroxyl radical scavenging and ATPase activity. Adeno-associated virus PHP.eB serotype that has high central nervous system transduction efficiency was applied to express Morc2a or Morc2a GHKL ATPase domain protein in vivo. AAV gene therapy improved neuropathy and muscular dysfunction with single-time treatment. The loss of function characteristics due to protein synthesis defect in Morc2a p.S87L was also observed in human MORC2 p.S87L or p.R252W variant, suggesting a relevance between mouse and human pathogenesis. Here, we demonstrate Morc2a p.S87L variant causes hydroxyl radical-mediated neuropathy and could be rescued through AAV-based gene therapy.

2024-02-06 | GSE235918 | GEO

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| 2388220 | ecrin-mdr-crc

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