Proteomics

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Advancing DIA-Based Limited Proteolysis Workflows: Introducing DIA-LiPA


ABSTRACT: This dataset supports evaluation of library-free DIA workflows for limited proteolysis mass spectrometry (LiP-MS) using a treatment-control experiment. It evaluates DIA-NN and Spectronaut and introduces DIA-LiPA, a pipeline for structural interpretation from semi-tryptic peptides and missing data, enhancing sensitivity and reproducibility in LiP-MS analysis.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Kris Gevaert  

PROVIDER: MSV000099740 | MassIVE | Tue Nov 04 01:56:00 GMT 2025

SECONDARY ACCESSION(S): PXD070283

REPOSITORIES: MassIVE

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