Proteomics

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Dataset for 3,3'-Dichlorobiphenyl (PCB 11) Alters the Hepatic Expression of Cytochrome P450 Enzymes in the Liver of Mouse Dams Exposed Orally During Pregnancy and Lactation

ABSTRACT: As part of a larger study on neurodevelopmental effects of lower chlorinated PCB 11, we characterized PCB 11 distribution in postweaning mouse dams orally developmentally exposed to PCB 11 via the diet. We used and liquid chromatography tandem mass spectrometry (LC MS/MS) based proteomics to map changes in hepatic protein levels following PCB 11 exposure, gas chromatography tandem mass spectrometry (GC MS/MS) to quantify PCB 11 and its metabolites in brain, liver, and serum; and liquid chromatograph-high resolution mass spectrometry (LC HRMS) to screen serum for additional PCB 11 metabolites. The accompanying dataset contains raw and processed files from the proteomic analysis only, including protein identification from AMICA, and network interaction data from STRING.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Hans-joachim Lehmler  

PROVIDER: MSV000099827 | MassIVE | Mon Nov 10 11:56:00 GMT 2025

SECONDARY ACCESSION(S): PXD070556

REPOSITORIES: MassIVE

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3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation.

Roach Crystal M CM   Koester Nate R NR   Li Xueshu X   Ahn Jeonghyeon J   Pope R Marshall RM   Wilson Rebecca J RJ   Mendieta Rosalia R   Valenzuela Anthony A   Han Weiguo W   Ding Xinxin X   Lein Pamela J PJ   Lehmler Hans-Joachim HJ  

Archives of toxicology 20251208

Healthy maternal metabolism is critical during pregnancy and lactation to support fetal development and protect against environmental toxins. Polychlorinated biphenyl 11 (PCB 11), a lower-chlorinated, non-legacy congener, is detected in human serum, including pregnant women and children; however, its impact during these sensitive life stages remains poorly understood. This study presents the first comprehensive hepatic proteome analysis of mouse dams exposed to PCB 11 during pregnancy and lactat  ...[more]

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