PAGE4 phosphorylation links MED12 G44D mutation to uterine fibroid progression
Ontology highlight
ABSTRACT: Uterine leiomyomas (ULs, or fibroids) are the most prevalent clinically significant tumors in reproductive-aged women, frequently causing abnormal uterine bleeding, pelvic pain, and infertility. Although surgical resection is effective for these benign neoplasms, the development of non-invasive, targeted therapies is an urgent clinical need. To bridge the gap between genotype and phenotype in ULs, we employed an integrated multi-omics strategy focused on the recurrent MED12 p.G44D mutation.
INSTRUMENT(S): timsTOF, Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER:
Markku Varjosalo
PROVIDER: MSV000100276 | MassIVE | Thu Dec 18 08:44:00 GMT 2025
REPOSITORIES: MassIVE
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