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Nuclear proteome map of mouse heart chamber

ABSTRACT: Heart specialisation involves nuclear programs however chamber-specific regulation of the nuclear proteome landscape remains unknown. In this study we isolated the nucleus from four major anatomical regions of healthy mouse heart (fresh) and employed quantitative mass spectrometry-based proteomics DIA-MS to construct a comprehensive nuclear proteome landscape. We also define a set of 932 proteins that were highly conserved across all anatomical regions, including transcription-regulator complexes, nucleolar/ribosome-associated, RNA-processing, and chromatin-organization components

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: David Greening

PROVIDER: MSV000100433 | MassIVE | Sat Jan 10 20:17:00 GMT 2026

SECONDARY ACCESSION(S): PXD072889

REPOSITORIES: MassIVE

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