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Probiotics-Mediated Reduction of Inflammatory Gut-Bacteria Improves MASLD via Fecal Lipidome Remodeling

ABSTRACT: This dataset contains raw high-resolution mass spectrometry data from a randomized controlled trial evaluating probiotic supplementation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) (ClinicalTrials.gov Identifier: NCT04555434). Participants received placebo or probiotic capsules containing Pediococcus pentosaceus, Lactobacillus lactis, or Lactobacillus helveticus for 8 weeks. Fecal samples collected before and after intervention from participants with high medication adherence (at least 98%) were analyzed using untargeted metabolomic and lipidomic profiling. The data capture probiotic-associated alterations in fecal metabolites and lipid species related to gut-liver axis modulation and hepatic function.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Hyeon-Seong Lee

PROVIDER: MSV000100934 | MassIVE | Sun Feb 22 23:39:00 GMT 2026

REPOSITORIES: MassIVE

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