Ontology highlight
ABSTRACT:
INSTRUMENT(S): UHPLC system (1290 Agilent), 6490 Triple Quadrupole LC/MS (Agilent), Bruker
SUBMITTER: Sara Samino
PROVIDER: MTBLS103 | MetaboLights | 2015-04-09
REPOSITORIES: MetaboLights
Scientific reports 20150623
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in ...[more]