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The nasal microbiome and metabolites are altered in depression patients

ABSTRACT: Depressive disorder is a heterogeneous neuropsychiatric disorder. It affects millions of people worldwide. The exact causes of depressive behavior remain unclear and are believed to implicate both genetic and environmental factors. In the past decade, there have been numerous studies on the dysbiosis of gut microbiota in patients with depression and animal models. Of particular note is the role of gut brain axis regulation, in which a series of continuously expanding microbial metabolites, including short chain fatty acids and neurotransmitters, have been identified as signaling molecules that affect behavioral outcomes. However, most insights about the association between microbiota and depression still focus on the gut-brain axis and ignore that nasal microbiota could form a complex and essential link with the nervous system via the nose-to-brain pathway. So far, the potential influence of the nasal microbiome on neurological disorders has been largely overlooked. We investigated the impact of nasal microbiota and nasal metabolites on depression in this study.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

PROVIDER: MTBLS10742 | MetaboLights | 2025-07-21

REPOSITORIES: MetaboLights

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	H100.mzXML	Mzxml
	H103.mzXML	Mzxml
	H105.mzXML	Mzxml
	H110.mzXML	Mzxml
	H113.mzXML	Mzxml

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