1H-NMR-based metabolomic analysis identifies disrupted glutamate metabolism as distinct serum signature in Parkinson’s disease patients

ABSTRACT: Using High-Performance Liquid Chromatography, we recently demonstrated a complex dysregulation of the glutamate NMDA receptor-stimulating amino acids in the brain, CSF and serum of Parkinson’s disease (PD) experimental models and patients. Here, we investigate the serum metabolomic profile in the same PD patients and healthy controls (HC) cohorts through an untargeted 1H-Nuclear Magnetic Resonance approach. We found that serum Glutamate levels discriminated PD and HC groups with high diagnostic accuracy.

INSTRUMENT(S): Nuclear Magnetic Resonance (NMR) -

PROVIDER: MTBLS10958 | MetaboLights | 2024-11-08

REPOSITORIES: MetaboLights