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Nitisinone’s mosquitocidal properties hold promise for malaria control

ABSTRACT:

Nitisinone’s mosquitocidal properties hold promise for malaria control

INSTRUMENT(S): Liquid Chromatography MS - positive - hilic, Liquid Chromatography MS - negative - hilic

PROVIDER: MTBLS11617 | MetaboLights | 2025-06-16

REPOSITORIES: MetaboLights

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			Action	DRS
	A1.mzXML	Mzxml
	A1.raw	Raw
	A1_neg.mzXML	Mzxml
	A2.mzXML	Mzxml
	A2.raw	Raw

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Publications

<i>Anopheles</i> mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone.

Haines Lee R LR Trett Anna A Rose Clair C García Natalia N Sterkel Marcos M McGuinness Dagmara D Regnault Clément C Barrett Michael P MP Leroy Didier D Burrows Jeremy N JN Biagini Giancarlo G Ranganath Lakshminarayan R LR Aljayyoussi Ghaith G Acosta-Serrano Álvaro Á

Science translational medicine 20250326 791

One approach to interrupting the transmission of insect-borne diseases that is successfully used in veterinary medicine is exploiting the ability of antiparasitic drugs to make vertebrate blood toxic for blood-feeding insects. Recent studies have identified 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme of the tyrosine detoxification pathway, as essential for hematophagous arthropods to digest their blood meals. Such blood-feeding insects include anopheline mosquitoes, which transmit mala ...[more]

PMID: 40138457

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