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Dubosiella sp. alleviates hypertension with improving arachidonic acid metabolism

ABSTRACT:

We identify a novel microbiota-driven anti-hypertensive mechanism mediated by Achyranthes bidentata (Ab) extract and gut microbe Dubosiella sp.. Using a hypertensive mouse model induced by L-NAME and a high-salt diet, we show that Ab extract significantly ameliorates hypertension and renal damage by selectively enriching Dubosiella in the gut microbiota. Metabolomics suggested that Ab significantly changed the metabolic profiles and enriched the lipid metabolism including arachidonic acid metabolism. In vitro, Ab significantly promote the biofilm formation of Dubosiella DSM103457. Further gavage experiments with Dubosiella DSM103457 confirmed its effects of alleviating hypertension and heart injury. Microbial and metabolic profiling via 16S rRNA sequencing, metagenomics and metabolomics revealed that Dubosiella DSM103457 modulates arachidonic acid metabolism, restoring critical prostaglandins and leukotrienes associated with cardiovascular homeostasis.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

PROVIDER: MTBLS12017 | MetaboLights | 2025-04-02

REPOSITORIES: MetaboLights

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			Action	DRS
	NEG_Dub_1.raw	Raw
	NEG_Dub_11.raw	Raw
	NEG_Dub_13.raw	Raw
	NEG_Dub_14.raw	Raw
	NEG_Dub_15.raw	Raw

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Achyranthes bidentata alleviates hypertension with regulating gut microbiota

Project description:Background: Hypertension remains a significant global health challenge, with limited treatment efficacy in many patients. Emerging evidence suggests that gut microbiota plays a crucial role in blood pressure regulation. This study investigates the anti-hypertensive effects of Achyranthes bidentata (Ab) extract and its interaction with the gut microbiota, particularly focusing on the enrichment of Dubosiella sp. and its impact on arachidonic acid metabolism.Results: Here, we identified a novel microbiota-driven anti-hypertensive mechanism mediated by the Ab extract and Dubosiella sp. Ab significantly ameliorated hypertension and kidney damage by enriching Dubosiella in hypertensive mice. Metabolomics analysis revealed that Ab enhances lipid metabolic pathways, particularly arachidonic acid metabolism. In vitro, Ab significantly promoted the biofilm formation of D. newyorkensis DSM103457. Further gavage experiments confirmed that D. newyorkensis DSM103457 alleviates hypertension, cardiac and kidney injury. Combined microbial and metabolic profiling via 16S rRNA sequencing, metagenomics and metabolomics demonstrated that D. newyorkensis DSM103457 modulates gut microbiota, arachidonic acid metabolism, restoring prostaglandins and leukotrienes essential for cardiovascular homeostasis. Notably, arachidonic acid significantly promotes D. newyorkensis DSM103457 growth, enabling rapid generation and transformation of HETEs and HODEs in vitro.Conclusions: This study identified Ab-Dubosiella-arachidonic acid axis as a novel anti-hypertensive pathway, offering promise for the development of integrated herbal prebiotics and microbial probiotics for targeted hypertension therapy.

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