Metabolomics,Multiomics

Dataset Information

14

Large-scale non-targeted plasma metabolomics in the Uppsala Longitudinal Study of Adult Men

ABSTRACT: The Uppsala Longitudinal Study of Adult Men (ULSAM) study is an ongoing, longitudinal, epidemiologic study started in 1970 and based on men born between 1920 and 1924 in Uppsala, Sweden which were invited to participate at age 50 (N=2,841) [PMID: 9484991]; 81.7% (N=2,322) participated. Individuals were reinvestigated at the ages of 60, 70, 77, 82 and 88 years. Information collected includes a medical questionnaire, blood pressure and anthropometric measurements, glucose tolerance test and 24-hour ambulatory blood pressure. Metbaolomics has been performed on plasma samples from age 70. In the final analysis we included samples from 1,138 individuals.

OTHER RELATED OMICS DATASETS IN: PRJNA125229

INSTRUMENT(S): Xevo G2 QTOF (Waters)

SUBMITTER: Andrea Ganna 

PROVIDER: MTBLS124 | MetaboLights | 2015-03-23

REPOSITORIES: MetaboLights

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Publications

Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events in 1,028 individuals (131 events; 10 y. median follow-up) with validation in 1,670 individuals (282 events; 3.9 y. median follow-up). Four metabolites were replicated and independent of main cardiovascula  ...[more]

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