Nutrient depletion and systems-wide metabolic shifting in polymer-producing wastewater bacterium

ABSTRACT:

Inorganic nutrient deficiency stimulates polymer synthesis in bacterial producers relevant to wastewater treatment and biotechnology, but the metabolic mechanisms are poorly understood. Here, using a quantitative multi-omics analysis of the wastewater isolate Comamonas testosteroni during nitrogen and phosphorus depletion, we uncover widespread metabolic rebalancing of carbon and energy fluxes beyond the synthesis of polyhydroxyalkanoate and glycogen, thereby revealing other key metabolic phenotypes important for surviving nutrient limitation with additional relevance to biotechnology applications. 

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase

PROVIDER: MTBLS12449 | MetaboLights | 2026-09-09

REPOSITORIES: MetaboLights