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Effects of nicotine on SH-SY5Y cells: an NMR-based metabolomic study

ABSTRACT:

Nicotine is a naturally occurring alkaloid primarily found in Nicotiana tabacum. This phytochemical is well known for its addictive properties, and its consumption—particularly through tobacco smoking—is strongly associated with an increased risk of malignancies, metabolic dysfunctions, and cardiovascular as well as respiratory diseases. Despite these adverse effects, several studies have also reported beneficial actions of nicotine, including the enhancement of cognitive functions in several neurodegenerative diseases. To better elucidate the multiple effects of nicotine and clarify their underlying mechanisms, we performed an NMR-based metabolomic analysis of SH-SY5Y neuroblastoma cells exposed to nicotine action. Our results indicate that nicotine modulates mitochondrial function and membrane turnover, thereby influencing mitochondrial bioenergetics, synaptic plasticity, and connectivity. Collectively, these findings may contribute, at least in part, to explain the neuroprotective effects of nicotine described in preclinical models of neurodegenerative disease.

INSTRUMENT(S): Nuclear Magnetic Resonance (NMR) -

PROVIDER: MTBLS12848 | MetaboLights | 2026-06-26

REPOSITORIES: MetaboLights

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			Action	DRS
	a_MTBLS12848_NMR___metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS12848_NMR___metabolite_profiling_v2_maf.tsv	Tabular
	s_MTBLS12848.txt	Txt

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