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Mitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

ABSTRACT:

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness markers and enhancing chemosensitivity to temozolomide (TMZ). To improve delivery, a CD133 aptamer-modified liposome-coated mitochondrial system (Apt/Lipo-Mito Gel) was developed, using alginate hydrogel as a post-surgical reservoir for sustained mitochondrial release, offering a novel metabolic therapy strategy for GBM.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

PROVIDER: MTBLS12901 | MetaboLights | 2025-08-27

REPOSITORIES: MetaboLights

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			Action	DRS
	a_MTBLS12901_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS12901_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS12901_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular
	m_MTBLS12901_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular

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