Dataset Information

PCOS preterm plasma metabolome

ABSTRACT:

This study investigated mid-trimester plasma metabolomic profiles in pregnant women to identify biomarkers associated with Polycystic Ovary Syndrome (PCOS) and preterm birth. A total of 149 participants were categorized into four groups: 32 with PCOS and preterm delivery, 34 with PCOS and term delivery, 42 without PCOS with preterm delivery, and 41 without PCOS with term delivery. Plasma samples were analyzed using targeted metabolomics via UHPLC-QTRAP MS/MS with HILIC and C18 chromatography. Multivariate statistical analyses including OPLS-DA were employed to identify significantly altered metabolites. The findings aim to provide insights into metabolic mechanisms underlying PCOS and preterm birth, potentially contributing to improved risk prediction strategies.

INSTRUMENT(S): Liquid Chromatography MS - alternating - HILIC, Liquid Chromatography MS - alternating - reverse phase

PROVIDER: MTBLS12968 | MetaboLights | 2025-09-09

REPOSITORIES: MetaboLights

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			Action	DRS
	a_MTBLS12968_LC-MS_alternating_hilic_metabolite_profiling.txt	Txt
	a_MTBLS12968_LC-MS_alternating_reverse-phase_metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS12968_LC-MS_alternating_hilic_metabolite_profiling_v2_maf.tsv	Tabular
	m_MTBLS12968_LC-MS_alternating_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular

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Project description:Preterm birth is a main determinant of neonatal mortality and morbidity and a major contributor to the overall mortality and burden of disease. However, precise phenotyping of the preterm birth is hampered by the imprecise definition of the clinical phenotype and complexity of the molecular phenotype due to multiple pregnancy tissue types and molecular processes that may contribute to the preterm birth. The studyâ??s aim was to comprehensively evaluate the mRNA transcriptome that characterizes preterm and term labor using precisely phenotyped samples. Expression profiles of 73 genes and non-coding RNA sequences uniquely identified the four groups of patients: delivering preterm with (PL) and without labor (PNL), term with (TL) and without labor (TNL). The largest differences in gene expression among the four groups occurred in decidua, chorion and amnion. The gene expression profiles showed suppression of chemokines expression in TNL, withdrawal of this suppression in TL, activation of multiple pathways of inflammation in PL, and an immune rejection profile in PNL. The genes constituting expression signatures showed over-representation of three putative regulatory elements in their 5â?? and 3â??UTR regions. The results suggest that pregnancy is maintained by downregulation of chemokines at the maternal-fetal interface. Withdrawal of this downregulation results in the term birth and its overriding by the activation of multiple pathways of the immune system in the preterm birth. Complications of the pregnancy associated with impairment of placental function, which necessitated premature delivery of the fetus in the absence of labor, show gene expression patterns associated with immune rejection. 183 total RNA samples from 8 tissue types collected from 35 women grouped into six categories of pregnancy outcome. One microarray replicate per sample. Other Contributors: Radek Bukowski, Sam Parry and the NICHD Genomic and Proteomic Network for Preterm Birth Research

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PCOS preterm plasma metabolome

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