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Untargeted LC–MS serum metabolomics in a colitis mouse model treated with the microbiota-regulating nanomedicine MRA@RP

ABSTRACT:

This study applies untargeted liquid chromatography–mass spectrometry (LC–MS)–based serum metabolomics to characterize metabolic alterations in a dextran sulfate sodium–induced colitis mouse model and to evaluate the therapeutic effects of the microbiota-regulating nanomedicine MRA_RP. Serum samples from healthy, colitis control and MRA_RP-treated mice were analyzed, and multivariate statistics (including PCA and volcano plots) were used to identify differentially abundant metabolites. MRA_RP treatment shifted the metabolic profile of colitis mice toward that of healthy controls. These data support a role for MRA_RP in comprehensive metabolic reprogramming linked to gut microbiota modulation, contributing to the amelioration of ulcerative colitis and related neuropsychiatric symptoms.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS13367 | MetaboLights | 2025-11-22

REPOSITORIES: MetaboLights

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			Action	DRS
	a_MTBLS13367_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS13367_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS13367_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular
	m_MTBLS13367_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular

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