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A Calorie-restricted Dietary Intervention Alleviates Obesity-induced MASLD via the Microbiota-5-hydroxyindoleacetic acid–Pregnane X Receptor Axis

ABSTRACT:

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents the most common chronic liver disease worldwide. Caloric restriction (CR) is a major dietary intervention known to reshape the gut microbiota; however, the implications of these microbial changes for MASLD pathophysiology are not yet fully elucidated. We propose a new caloric restriction intervention which ameliorates MASLD by shaping the gut microbiome that elevates 5-HIAA levels, thereby activating the hepatic PXR receptor.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS13675 | MetaboLights | 2026-01-14

REPOSITORIES: MetaboLights

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			Action	DRS
	a_MTBLS13675_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS13675_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS13675_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular
	m_MTBLS13675_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular

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