Microbiome and metabolome patterns centered on cancer cachexia link skeletal muscle and adipose tissue depletion to clinical outcomes in locally advanced rectal cancer

ABSTRACT:

This study employed untargeted serum metabolomics to delineate the specific metabolic landscape of cancer cachexia in patients with locally advanced rectal cancer. By analyzing LC-MS raw data from 133 patients (64 discovery, 69 validation), we identified and validated key cachexia-associated metabolites, including lithocholic acid and cortisone. These metabolites were closely linked to gut microbial dysbiosis and loss of skeletal muscle and adipose tissue, collectively defining a cachexia-associated gut microbiome–metabolome–host tissue axis. This dataset provides essential molecular-level support for understanding the metabolic basis of cachexia and its inter-individual heterogeneity in clinical outcomes.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS13787 | MetaboLights | 2026-05-09

REPOSITORIES: MetaboLights