Metabolomic Reprogramming Induced by Conjugative Acquisition of Carbapenemase-producing IncX3 Plasmid Revealed by Untargeted LC-MS/MS Profiling

ABSTRACT:

This study aimed to elucidate the metabolic process of IncX3 plasmid within conjugated strains, by utilizing untargeted LC-MS/MS profiling. In this study, the blaNDM-5-carrying IncX3 plasmid was successfully conjugated into Escherichia coli J53, which was confirmed to enhance both carbapenem resistance and host fitness. Untargeted LC-MS/MS profiling revealed strategic remodeling response induced by the acquisition of the IncX3 plasmid.

INSTRUMENT(S): Liquid Chromatography MS - positive

PROVIDER: MTBLS13918 | MetaboLights | 2026-09-27

REPOSITORIES: MetaboLights