Metabolomics

Dataset Information

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Cross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart


ABSTRACT: In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondria. GE-EVs therapy restores mitochondrial integrity and ATP synthesis through mitochondrial quality control, thereby reversing myocardial hypoxia and attenuating ROS production.

INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic

PROVIDER: MTBLS14245 | MetaboLights | 2026-04-09

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
a_MTBLS14245_LC-MS_alternating_hilic.txt Txt
i_Investigation.txt Txt
m_MTBLS14245_LC-MS_alternating_hilic_v2_maf.tsv Tabular
s_MTBLS14245.txt Txt
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