Metabolomics

Dataset Information

Cross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart

ABSTRACT: In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondria. GE-EVs therapy restores mitochondrial integrity and ATP synthesis through mitochondrial quality control, thereby reversing myocardial hypoxia and attenuating ROS production.

INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic

PROVIDER: MTBLS14245 | MetaboLights | 2026-04-09

REPOSITORIES: MetaboLights

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E-GH-1.mzML Mzml
E-GH-2.mzML Mzml
E-GH-3.mzML Mzml
E-GH-4.mzML Mzml
E-GH-5.mzML Mzml
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