Effects of oral ketone ester administration in a pMCAO model (KetoSTROKE study)

ABSTRACT:

Rapid, deep, and sustained systemic ketosis was achieved using an orally administered ketone ester (KE: 3.0 mg/g body weight of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate; DeltaG® Ketone Ester, TΔS® Ltd, Oxfordshire, UK) compared with control (0.9% NaCl) prior to permanent middle cerebral artery occlusion (pMCAO; n=5 mice per group). The severity of cerebral ischemia was assessed in vivo by MRI at 60 minutes after arterial occlusion. To investigate the underlying mechanisms, ex vivo metabolomic analysis of brain tissue was performed. The brain was separated into the ischemic hemisphere and the contralateral control hemisphere.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS14363 | MetaboLights | 2026-04-24

REPOSITORIES: MetaboLights