Metabolome of 334 cerebral thrombi (in four batches) retrieved by mechanical thrombectomy after ischemic stroke due to large vessel occlusion (Retro-MATISSE study)

ABSTRACT:

The Retro-MATISSE study (Molecular Analysis of Thrombus for Ischemic Stroke prognosiS and Etiology) aimed to characterize the metabolome of 334 thrombi retrieved by mechanical thrombectomy after ischemic stroke due to large vessel occlusion. LC–MS analysis of the thrombi was performed in four batches:

• Batch 1: NCE1 to NCE60 (59 samples)

• Batch 2: MAR1 to MAR47 (47 samples)

• Batch 3: MAR50 to MAR157 (103 samples)

• Batch 4: MAR158 to MAR282 (125 samples)

Some patients received intravenous thrombolytic therapy with rt-PA prior to mechanical thrombectomy, in accordance with current guidelines. The objective of this study was to identify molecular signatures of thrombi associated with different clinical outcomes, including resistance to thrombolytic therapy, arterial recanalization rate, functional outcome, and the etiology of cerebral infarction.

INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic, Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS14374 | MetaboLights | 2026-04-25

REPOSITORIES: MetaboLights