Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolomic profiling of Kitasatospora aureofaciens overexpressing the alpha subunit of acyl-CoA carboxylase

ABSTRACT: This study contains metabolomics data from Kitasatospora aureofaciens ATCC 10762 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA precursor supply, and polyketide biosynthesis.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS14444 | MetaboLights | 2026-05-06

REPOSITORIES: MetaboLights

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	a_MTBLS14444_LC-MS_negative_reverse-phase.txt	Txt
	a_MTBLS14444_LC-MS_positive_reverse-phase.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS14444_LC-MS_negative_reverse-phase_v2_maf.tsv	Tabular
	m_MTBLS14444_LC-MS_positive_reverse-phase_v2_maf.tsv	Tabular

Items per page:

1 - 5 of 6

Similar Datasets

Metabolomic profiling of Streptomyces coelicolor overexpressing the alpha subunit of acyl-CoA carboxylase

Project description:This study contains metabolomics data from Streptomyces coelicolor M145 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA precursor supply, and polyketide biosynthesis.

2026-05-06 | MTBLS14439 | MetaboLights

Metabolomic profiling of Streptomyces virginiae overexpressing the alpha subunit of acyl-CoA carboxylase

Project description:This study contains metabolomics data from Streptomyces virginiae CGMCC 4.1619 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA precursor supply, and polyketide biosynthesis.

2026-05-06 | MTBLS14442 | MetaboLights

Metabolomic profiling of Streptomyces ambofaciens overexpressing the alpha subunit of acyl-CoA carboxylase

Project description:<p>This study contains metabolomics data from Streptomyces ambofaciens CGMCC 4.1528 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA precursor supply, and polyketide biosynthesis.</p>

2026-05-06 | MTBLS14441 | MetaboLights

Carboxyltransferase Subunit of the Acyl-CoA Carboxylase in Mycobacterium tuberculosis.

Project description:The Mycobacterium tuberculosis acyl-CoA carboxylases provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase (FAS) I and for the elongation of FAS I end-products by the FAS II complex to produce meromycolic acids. M. tuberculosis genome contains three biotin carboxylase subunits (AccA1-3) and 6 carboxyltransferase subunits (AccD1-6) of which AccD6 is located in a genetic locus that contains members of the FAS II complex. We found by microarray and quantitative real-time RT-PCR analysis that the transcripts of AccA3, AccD4, AccD5 and AccD6 are expressed at high levels during exponential growth phases of M. tuberculosis in vitro. Keywords: Time course, developmental stages

2006-10-07 | GSE5977 | GEO

Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production

Project description:Heterologous expression of polyketide synthase (PKS) genes in Escherichia coli has enabled the production of various valuable natural and synthetic products. However, the limited availability of malonyl-CoA (M-CoA) in E. coli remains a significant impediment to high-titer polyketide production. In this study, we address this limitation by disrupting the native M-CoA biosynthetic pathway and introducing an orthogonal pathway comprising a malonate transporter and M-CoA ligase, enabling efficient M-CoA biosynthesis under malonate supplementation. This approach significantly increases M-CoA levels, enhancing fatty acid and polyketide titers while reducing the promiscuous activity of PKSs toward undesired acyl-CoA substrates. Subsequent adaptive laboratory evolution of these strains provides insights into M-CoA regulation and identifies mutations that further boost M-CoA and polyketide production. This strategy improves E. coli as a host for polyketide biosynthesis and advances understanding of M-CoA metabolism in microbial systems.

2025-02-13 | PXD060741 | Pride

H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ATAC-seq)

Project description:We investigated the combined effects of H4K16 acylations in vivo using a mouse model of short-chain acyl-CoA dehydrogenase deficiency (SCADD), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations modulate transcriptional responses in a concerted manner, providing insights into an adaptive chromatin regulation in response to metabolic stress.

2026-01-13 | GSE296976 | GEO

H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (RNA-seq)

2026-01-13 | GSE296978 | GEO

H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ChIP-seq)

2026-01-13 | GSE296977 | GEO

Acyl-coA Binding Protein neutralization improves cancer immunosurveillance

Project description:Acyl-coA Binding Protein neutralization improves cancer immunosurveillance

| PRJNA1011354 | ENA

Mycobacterium tuberculosis

Project description:Carboxyltransferase Subunit of the Acyl-CoA Carboxylase in Mycobacterium tuberculosis.

| PRJNA97455 | ENA