Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mechanism of Blueberry Anthocyanins in Ameliorating Radiation-Induced Intestinal Injury through Gut Microbiota Modulation

ABSTRACT: Radiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionising radiation, such as that employed in radiation therapy for malignant tumours in the abdominal or pelvic regions, within the treatment area. It is a prevalent and severe consequence of radiation therapy for abdominal and pelvic tumours, greatly affecting treatment outcomes and patients' quality of life. Western medicine primarily employs symptomatic management, including medical drug therapy, hyperbaric oxygen therapy, nutritional support therapy, endoscopic and surgical interventions, as well as stem cell transplantation. However, current therapeutic agents for RIII fall far short of achieving ideal outcomes. Previous studies indicate that blueberry anthocyanins (BA) possess not only anticancer properties but also potent anti-inflammatory, antioxidant, and anti-radiation activities.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS14609 | MetaboLights | 2026-05-29

REPOSITORIES: MetaboLights

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	a_MTBLS14609_LC-MS_negative_reverse-phase.txt	Txt
	a_MTBLS14609_LC-MS_positive_reverse-phase.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS14609_LC-MS_negative_reverse-phase_v2_maf.tsv	Tabular
	m_MTBLS14609_LC-MS_positive_reverse-phase_v2_maf.tsv	Tabular

Items per page:

1 - 5 of 6

Similar Datasets

Expression data from distal colorectal tissues of Pdgfc+/+ and Pdgfc-/- mice with or without irradiation

Project description:Radiation therapy for malignancies in the pelvic region leads to a crucial complication called radiation proctopathy(RP) with acute changes in bowel habits or long-term morbidity. We used microarrays to detail the genome-wide profiles of mice with different genotypes (Pdgfc+/+ and Pdgfc-/- ) under irradiation treatment or not.

2021-08-24 | GSE145131 | GEO

RNA-seq profiling of mouse small intestine treated with intravenous immunoglobulin (IVIg) after total abdominal irradiation

Project description:Radiation-induced enteritis (RIE) is a common and severe adverse effect of radiotherapy for abdominal and pelvic tumors, with limited effective treatments. We previously demonstrated that intravenous immunoglobulin (IVIg) alleviates radiation toxicity, but its mechanism of action on intestinal stem cell (ISC) regeneration remains unclear. Here, we performed RNA-seq on the small intestine of mice with radiation-induced enteritis to investigate the transcriptomic changes induced by IVIg treatment. Total abdominal irradiation (TAI, 12 Gy) was performed on C57BL/6J mice, followed by intravenous administration of IVIg (500 mg/kg) within 1 h after irradiation. Jejunal tissues were collected on Day 3 post-irradiation for RNA-seq analysis. Our results show that IVIg treatment significantly altered the expression of genes related to cell proliferation, inflammation, oxidative stress, and the Wnt/β-catenin signaling pathway, which is critical for ISC maintenance and regeneration. These data provide a molecular basis for the radioprotective effect of IVIg in mitigating RIE, supporting its potential as a therapeutic candidate for this condition.

2026-04-30 | GSE329124 | GEO

Mechanism of radiation-induced liver disease based on single-cell transcriptomics

Project description:We report single-cell transcriptomic analyses of whole livers from irradiated and controlled Sprague‒Dawley (SD) rats. The aim of the study was to elucidate the molecular and cellular drivers of radiation-induced liver disease (RILD), a serious complication of radiation therapy for upper abdominal tumors in humans.

2026-03-11 | GSE293378 | GEO

BMX-001, a selective radioprotector in phase II clinical trials, can reverse radiation-induced fibrosis when given three weeks after radiation

Project description:Radiation provides excellent tumor control in prostate cancer yet unavoidably harms adjacent healthy tissue via the generation of reactive oxygen species (ROS). Radiation-induced ROS is known to impact fibroblasts long after radiation, resulting in radiation-induced fibrosis (RIF), which can cause incontinence and other side effects that reduce patient quality of life. BMX-001, a manganese porphyrin designed to mimic superoxide dismutase, is in clinical trials as a selective radioprotector when given before and during radiation therapy. However, there have been no studies evaluating BMX-001 when given after radiation for its impacts on RIF. Mice were given pelvic radiation (7.5 Gy for 5 consecutive days) followed by BMX-001 three weeks after radiation. Fibroblasts and tissues were isolated two months following radiation. We found that BMX-001 returned radiation-induced alterations in fibroblast morphology to normal and reversed markers of fibroblast activation and senescence. BMX-001 also decreased collagen deposition six months after radiation. We found that overall, radiation resulted in reduced methylation two months after radiation, and BMX-001 administered three weeks after radiation modulated radiation-altered methylation patterns back to normal and restored normal expression of a fibrosis-associated gene CAMK2beta. BMX-001 also decreased radiation-induced DNA adduct 8-hydroxy-2’-deoxyguanosine (8-OHdG), which is known to interfere with methylation. BMX-001 was able to prevent DNA oxidation and restore normal methylation patterns in an oligonucleotide model of DNA oxidation and methylation. This study reveals the feasibility of agents to reverse fibrosis in pelvic radiation and suggests that BMX-001 may be effective when given after radiation.

2026-01-28 | GSE308163 | GEO

BMX-001, a selective radioprotector in phase II clinical trials, can reverse radiation-induced fibrosis when given three weeks after radiation [Bisulfite-seq]

2026-01-28 | GSE309064 | GEO

Changes in transcription profile in pelvic organ fibroblasts in response to stretch

Project description:Failure of ligamentous support of the genital tract to resist intra-abdominal pressure is a plausible underlying mechanism for the development of pelvic organ prolapse, but the nature of molecular response of pelvic tissue support remains unknown. We hypothesized that the expression of genes coding for proteins involved in maintaining the cellular and extracellular integrity would be altered in cases of pelvic organ prolapse. Therefore, cDNA microarrays were used to examine the difference in transcriptional profile in RNA of primary culture fibroblasts subjected to mechanical stretch and those that remained static. Keywords: Changes in transcription profile in pelvic organ fibroblasts in response to stretch

2007-01-26 | GSE6862 | GEO

mRNA expression analysis of mice intestine profiles between PBS and free ubiquitin after irradiation

Project description:This study aims to compared mRNA expression between PBS- and free ubiquitin-treated intestines after 7 Gy radiation (total body radiation) by microarray analysis. Mice intestine tissues were collected 3.5 days after radiation.

2019-06-27 | GSE133377 | GEO

Interleukin-4 modulates type I interferon to augment anti-tumour immunity [scRNA-Seq]

Project description:Despite advances in immunotherapy, metastatic melanoma remains a significant therapeutic challenge due to the complexity of the tumour microenvironment. Intratumoural type I interferon (IFN-I) has long been associated with improved clinical outcomes. However, several IFN-I subtypes can also paradoxically promote tumour growth in some contexts. We investigated this further by engineering murine B16 melanoma cells to overexpress various IFN-I subtypes, where a spectrum of outcomes was observed. Characterisation of these tumours by RNA-sequencing revealed a tumour immune phenotype, where potent IFN-I signalling concomitant with diminished type 2 inflammation failed to confer durable tumour control. T cell-mediated rejection of these tumours was restored by introducing interleukin (IL)-4 into the tumour microenvironment, either through ectopic expression or in a pre-clinical adoptive T cell therapy model. Collectively, our findings highlight the IFN-I/IL-4 axis in promoting anti-tumour immunity, which could be harnessed to target and stratify solid tumours that are non-responsive to frontline therapies.

2025-02-18 | GSE289723 | GEO

Interleukin-4 modulates type I interferon to augment anti-tumour immunity

2025-02-18 | GSE289722 | GEO

Time-course proteomic analysis of irradiated human endothelial cells

Project description:The vascular endothelium is a hot spot in the response to radiation therapy for both tumors and normal tissues. To improve patient outcomes, interpretable systemic hypotheses are needed to help radiobiologists and radiation oncologists propose endothelial targets that could protect normal tissues from the adverse effects of radiation therapy and/or enhance its antitumor potential. To this end, we captured the kinetics of multi-omics layers – i.e. miRNome, targeted transcriptome, proteome and metabolome – in irradiated primary human endothelial cells cultured in vitro. We then designed a strategy of deep learning as in convolutional graph networks that facilitates unsupervised high-level feature extraction of important omics data to learn how ionizing radiation-induced endothelial dysfunction may evolve over time. Last, we present experimental data showing that some of the features identified using our approach are involved in the alteration of angiogenesis by ionizing radiation.

2022-01-19 | PXD030572 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data