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Targeted polyamine metabolomics of ATP13A4-deficient cellular and mouse models

ABSTRACT:

ATP13A4 is a polyamine transporter enriched in astrocytes that regulates extracellular polyamine homeostasis. This study contains targeted LC-MS/MS metabolomics data from ATP13A4-deficient cellular and mouse models, including C8-D1A astrocytic cells, astrocyte-conditioned medium, mouse cortex, plasma and cerebrospinal fluid. Polyamines and acetylated polyamine derivatives were quantified following isobutyl chloroformate derivatization using Orbitrap mass spectrometry. The dataset supports the manuscript 'ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis' and investigates how ATP13A4 deficiency alters intracellular and extracellular polyamine distribution.

INSTRUMENT(S): Liquid Chromatography MS - positive - reversed-phase-c18

PROVIDER: MTBLS14724 | MetaboLights | 2026-06-10

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	a_MTBLS14724_LC-MS_positive_reversed-phase-c18-1.txt	Txt
	a_MTBLS14724_LC-MS_positive_reversed-phase-c18.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS14724_LC-MS_positive_reversed-phase-c18-1_v2_maf.tsv	Tabular
	m_MTBLS14724_LC-MS_positive_reversed-phase-c18_v2_maf.tsv	Tabular

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Targeted polyamine metabolomics of ATP13A4-deficient cellular and mouse models

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