Phenomic and multiomic characterisation of microsatellite-stable colorectal cancer reveals novel biology and targets of vulnerability

ABSTRACT:

Integrating data from approximately 2,000 tumour samples, corresponding to ~4,500 platform-specific multiomic sample profiles, and 195,246 single cells/nuclei from diverse in-house and publicly available datasets, single-to-integrated multiomic and clinical phenome data fusion analysis uncovers the mechanistic and molecular complexity of microsatellite-stable colorectal cancer (MSS CRC). Nevertheless, we identify potentially actionable vulnerability targets validated in state-of-the-art patient-derived tumouroid and xenograft models. Overall, we propose FAK, PDK1/2 (PIK3CA/AKT/mTOR), and proteasomal inhibitors, combined with trametinib, as translatable combinatorial treatment strategies.

INSTRUMENT(S): Flow injection analysis MS - negative

PROVIDER: MTBLS15127 | MetaboLights | 2026-09-15

REPOSITORIES: MetaboLights