Isoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis

ABSTRACT: High-altitude hypoxia induces myocardial metabolic disorders, structural remodeling, and functional impairment, which threaten the health of highland populations. The interventional effects and molecular mechanisms of isoquercitrin (IQ), a natural flavonoid with cardiovascular protective activity, against high-altitude hypoxic cardiac injury are unclear. Taken together, the results indicate that IQ mitigates subchronic high-altitude hypoxia-induced myocardial metabolic reprogramming and functional injury through multitarget synergistic regulation of the hematopoietic–immune–energy metabolic network, thus offering a novel therapeutic strategy for preventing and treating high-altitude heart disease.

INSTRUMENT(S): Liquid Chromatography MS - alternating - reverse-phase

PROVIDER: MTBLS15192 | MetaboLights | 2026-07-29

REPOSITORIES: MetaboLights