Dataset Information
Histone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma
Ontology highlight
ABSTRACT: This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulation in gastric cancer cells. Correlative bioinformatic analyses from TCGA cohort and paired clinical specimens support the RBP2&PPARgama regulatory axis. Cellular rescue assays and xenograft models further verify that PPARgama serves as a critical downstream mediator for RBP2 mediated lipid metabolic rewiring and gastric tumor progression.
INSTRUMENT(S): Liquid Chromatography MS - positive - hilic
PROVIDER: MTBLS15324 | MetaboLights | 2026-08-14
REPOSITORIES: MetaboLights
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| NC_1.zip | Other | |||
| NC_2.zip | Other | |||
| NC_3.zip | Other | |||
| siRBP2_1.zip | Other | |||
| siRBP2_2.zip | Other |
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