Aromatic amino acids metabolism shapes autophagy mediated adaptation to iron deprivation in glioma

ABSTRACT:

GBM displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in glioma remains incompletely understood. DFO, an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of autophagy, apoptosis, and ferroptosis under DFO-induced stress is unclear. This study aims to clarify how iron chelation reshapes stress signaling and metabolism in glioma cells and to define the role of aromatic amino acid metabolism in autophagy-mediated adaptation to iron deprivation.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - hilic, Liquid Chromatography MS - positive - reverse-phase, Liquid Chromatography MS - negative - hilic

PROVIDER: MTBLS15394 | MetaboLights | 2026-08-20

REPOSITORIES: MetaboLights